Since you’re running 2.2.1b2 - you should go ahead and update to the latest beta version which is 2.2.1b5. This has a few adjustments that will help it to work better under newer operating systems like you have.
https://www.chromix.com/colorthink/download
As for the File not tagged as ‘prof’ message: This is a common warning that ColorThink will bring up when you run the Profile Medic. It is not a serious problem, and might only affect older Mac systems. More info here:
http://www.colorwiki.com/wiki/ColorThink_Pro_-_Profile_Medic#Profile_Medic_Tests