This may or my not be related to ColorThink but I started having this problem shortly after I got the latest beta of ColorThink that finally allowed me to disable profiles. I have posted this in a couple of Photoshop forums as well.
I am having a strange problem where Photoshop will not be able to find any of the icc profiles that I have installed in my ~/Library/ColorSync/Profiles directory. They are still visible in Finder, ColorSync Utility and ColorThink.
It has been happening about once every two weeks or so. The only way I seem to be able to fix it is to remove all the profiles from my user Profiles directory, reboot the OS and copy them back.
I was wondering if anyone here had heard of anything like this happening. At first I thought it might be related to using ColorThink to “disable” unused profiles. But the last several times this happened I have not made any changes to any of my Profiles directories.